Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells

Xing Chen, Peng Wu, Michael Rousseas, David Okawa, Zev J. Gartner, Alex Zettl, Carolyn R. Bertozzi

Journal of the American Chemical Society · 2009 · 576 citations · 20 references

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Abstract

We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.

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