Nano Letters · 2006 · 1.1K citations · 11 references
Natural SciencesMaterials ScienceToxicologyBiomaterialsNanomaterialsToxicodynamicsCarbon NanomaterialsCarbon NanotubesNanoparticle CharacterizationNanoparticle SurfacesNanotoxicologyNanotubesCarbon NanofibersCarbon-based NanomaterialsMulti-walled Carbon NanotubesNanomaterial ToxicityNanoparticle CytotoxicityNanoparticle ToxicityNanoparticlesSize-dependent Toxicity
The study examined how aspect ratio and surface chemistry affect the cellular toxicity of carbon‑based nanomaterials. The authors tested multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles for toxicity in vitro on lung tumor cells. The materials were toxic, with size‑dependent effects, and cytotoxicity increased when particles were acid‑functionalized.
The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro on lung tumor cells. Our work clearly indicated that these materials are toxic while the hazardous effect is size-dependent. Moreover, cytotoxicity is enhanced when the surface of the particles is functionalized after an acid treatment.
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Nadine Wong Shi Kam, Michael O’Connell, Jeffrey Wisdom et al. · Proceedings of the National Academy of Sciences · 2005 · 2.3K citations · Full text