Compartmental Models for Apical Efflux by P-glycoprotein—Part 1: Evaluation of Model Complexity

Membrane lipid composition and cellular function.

A A Spector, Mark A. Yorek · Journal of Lipid Research · 1985 · 1.5K citations · Full text

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Oral Loperamide, Brain Penetration, Pharmacotherapy +20

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Immunology, Cellular Pharmacology, Pharmacotherapy +16

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

Mi Sun Jin, Michael L. Oldham, Qiuju Zhang et al. · Nature · 2012 · 453 citations · Full text

Crystal Structure, Proteinlipid Interaction, Biochemistry +8

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 399 citations