Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis

Abstract

DM and PM are diseases characterized by the systemic overexpression of IFNalpha/beta-inducible genes. The magnitude of the overexpression of these genes is higher in DM and correlates with disease activity in both disorders. Although PM and IBM have been modeled as having similar immunologic processes occurring within muscle, there are substantial differences in the expression of IFNalpha/beta-inducible genes in blood in these diseases.

References

Page 1

	Year	Citations
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Emily C. Baechler, Franak Batliwalla, George Karypis, Proceedings of the National Academy of Sciences	2003	2.2K
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood Lynda Bennett, Karolina Palucka, Edsel Arce, The Journal of Experimental Medicine VasculitisImmunologyPathologyImmunotherapyGranulopoiesis Signatures	2003	1.9K
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays Sandy D. Der, Aimin Zhou, Bryan Williams, Proceedings of the National Academy of Sciences GeneticsImmunologyMolecular BiologyGene CharacterizationMolecular Genetics	1998	1.8K
119th ENMC international workshop: Trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10–12 October 2003, Naarden, The Netherlands Jessica E. Hoogendijk, Anthony A. Amato, Bryan Lecky, Neuromuscular Disorders RheumatologyAutoimmune DiseaseEnmc International WorkshopRheumatic DiseasesClinical Trials	2004	914
Functional classification of interferon-stimulated genes identified using microarrays Michael J. de Veer, Michelle Holko, Mathias A.E. Frevel, Journal of Leukocyte Biology EngineeringGeneticsImmunologyGene CharacterizationGene Regulatory Network	2001	885
Interferon‐α/β–mediated innate immune mechanisms in dermatomyositis Steven A. Greenberg, Jack L. Pinkus, Geraldine S. Pinkus, Annals of Neurology	2005	602
Prednisone in Duchenne Dystrophy Robert C. Griggs Archives of Neurology	1991	276
Stochastic Models Inspired by Hybridization Theory for Short Oligonucleotide Arrays Zhijin Wu, Rafael A. Irizarry Journal of Computational Biology Expression ArraysMolecular BiologyBiological ComputingGene Expression ProfilingMolecular Computing	2005	266
Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray Guang‐Ming Han, Shu‐Ling Chen, Nan Shen, Genes and Immunity BioinformaticsAutoimmune DiseaseLupusGeneticsMedicine	2003	260
Molecular profiles of inflammatory myopathies Steven A. Greenberg, Despina Sanoudou, Judith N. Haslett, Neurology	2002	216

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