Concepedia

An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3

Félix A. Urra, Maximiliano Martínez‐Cifuentes, Mario Pavani, Michel Lapier, Fabián Jaña, Eduardo Parra, Juan Diego Maya, Hernán Pessoa‐Mahana, Jorge Ferreira, Ramiro Araya‐Maturana

Toxicology and Applied Pharmacology · 2013 · 32 citations · 32 references

DOIFull text

Open access

Concepts

References

32

Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production

Nianyu Li, Kathy Ragheb, Gretchen Lawler et al. · Journal of Biological Chemistry · 2003 · 1.4K citations · Full text

, , +17

Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

Nathan Majewski, Véronique Nogueira, Prashanth T. Bhaskar et al. · Molecular Cell · 2004 · 632 citations

, , +14

The bioenergetic signature of cancer: a marker of tumor progression.

José M. Cuezva, Maryla Krajewska, Miguel López de Heredia et al. · PubMed · 2002 · 439 citations

, , +17

Tumor pH controls the <i>in vivo</i> efficacy of weak acid and base chemotherapeutics

Leo E. Gerweck, Shashirekha Vijayappa, Sergey V. Kozin · Molecular Cancer Therapeutics · 2006 · 355 citations

, , +14

Effects of Deguelin on the Phosphatidylinositol 3-Kinase/Akt Pathway and Apoptosis in Premalignant Human Bronchial Epithelial Cells

Kyung‐Hee Chun, Jerome W. Kosmeder, Shi‐Yong Sun et al. · JNCI Journal of the National Cancer Institute · 2003 · 257 citations

, , +16