Prenylation of oncogenic human PTPcaax protein tyrosine phosphatases

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

Kiyoko Kato, Adrienne D. Cox, Mark M. Hisaka et al. · Proceedings of the National Academy of Sciences · 1992 · 541 citations

Life Sciences, Biochemistry, Molecular Biology +14

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

John F. Hancock, Karen A. Cadwallader, Hugh Paterson et al. · The EMBO Journal · 1991 · 492 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Laura Sepp‐Lorenzino, Zhuang Ma, Elaine Rands et al. · PubMed · 1995 · 384 citations

Medicine, Oncology, Pharmacology +15

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

Guy L. James, Joseph L. Goldstein, Michael S. Brown · Journal of Biological Chemistry · 1995 · 291 citations · Full text

Medicine, Cancer Biology, Pharmacology +14

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

Nancy E. Kohl, Francine R. Wilson, S D Mosser et al. · Proceedings of the National Academy of Sciences · 1994 · 285 citations

Medicine, Oncology, Pharmacology +13