Nuclear phosphoinositide 3-kinase C2β activation during G2/M phase of the cell cycle in HL-60 cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF‐I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus.

Nullin Divecha, Robin F. Irvine · The EMBO Journal · 1991 · 463 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system.

Stefano Volinia, Ritu Dhand, Bart Vanhaesebroeck et al. · The EMBO Journal · 1995 · 360 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

Jan Domin, Françoise Pagès, Stefano Volinia et al. · Biochemical Journal · 1997 · 250 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking

Ibragim Gaidarov, Mary Ellen Smith, Jan Domin et al. · Molecular Cell · 2001 · 227 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12