Hepatic Cystogenesis Is Associated with Abnormal Expression and Location of Ion Transporters and Water Channels in an Animal Model of Autosomal Recessive Polycystic Kidney Disease

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Christopher J. Ward, Marie C. Hogan, Sandro Rossetti et al. · Nature Genetics · 2002 · 763 citations

Medicine, Genetics, Molecular Genetics +14

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 632 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives

Z. Ioav Cabantchik, A. Rothstein · The Journal of Membrane Biology · 1972 · 533 citations

Natural Sciences, Biochemistry, Biophysics +11

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 532 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene, Encodes a Novel Large Protein Containing Multiple Immunoglobulin-Like Plexin-Transcription–Factor Domains and Parallel Beta-Helix 1 Repeats

Luiz F. Onuchic, Laszlo Furu, Yasuyuki Nagasawa et al. · The American Journal of Human Genetics · 2002 · 510 citations · Full text

Medicine, Genetics, Molecular Genetics +8