Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Life Sciences, Biochemistry, Molecular Biology +17

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

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Life Sciences, Biochemistry, Pharmacology +17

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems

Nicholas Bodor, Péter Buchwald · Advanced Drug Delivery Reviews · 1999 · 158 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Structure−Activity Relationships and Molecular Modeling of 3,5-Diacyl-2,4-dialkylpyridine Derivatives as Selective A₃ Adenosine Receptor Antagonists

An‐Hu Li, Stefano Moro, Neli Melman et al. · Journal of Medicinal Chemistry · 1998 · 122 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16