High incidence of interleukin 10 mRNA but not interleukin 2 mRNA detected in human breast tumours

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

René de Waal Malefyt, J S Abrams, B Bennett et al. · The Journal of Experimental Medicine · 1991 · 3.8K citations · Full text

Immunology, Immune Regulation, Immunologic Mechanism +19

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Adaptive Immune System, T-regulatory Cell, Viral Immunity +20

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

Linna Ding, Peter S. Linsley, Long Huang et al. · The Journal of Immunology · 1993 · 842 citations

T-regulatory Cell, Immune Regulation, Immunology +17

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation

René de Waal Malefyt, Hans Yssel, J E de Vries · The Journal of Immunology · 1993 · 612 citations · Full text

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

Alexander Enk, V L Angeloni, Mark C. Udey et al. · The Journal of Immunology · 1993 · 507 citations