Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Alberto Pugliese, Markus Zeller, Alarico Fernandez et al. · Nature Genetics · 1997 · 947 citations

Life Sciences, Genetics, Molecular Genetics +8

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

S. T. Bennett, Anneke Lucassen, Stephen Gough et al. · Nature Genetics · 1995 · 754 citations

Medicine, Genetics, Molecular Genetics +10

Evidence for a differential avidity model of T cell selection in the thymus

Philip G. Ashton‐Rickardt, António Bandeira, Joseph R. Delaney et al. · Cell · 1994 · 665 citations

Life Sciences, Cell Biology, Immunology +12

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

Eric Sebzda, Valerie A. Wallace, John P. Mayer et al. · Science · 1994 · 489 citations

Life Sciences, Immunology, Adaptive Immunity +16

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

Giulia C. Kennedy, Michael S. German, William J. Rutter · Nature Genetics · 1995 · 382 citations

Life Sciences, Genetics, Molecular Genetics +9