Enzymatic synthesis of proteins and peptides

Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibriums toward synthesis

Gene A. Homandberg, Jeffrey A. Mattis, M. Laskowski · Biochemistry · 1978 · 244 citations

Life Sciences, Biochemistry, Chemistry +12

THE RÔLE OF SPECIFICITY IN THE ENZYMATIC SYNTHESIS OF PROTEINS

Max Bergmann, H. Fraenkel‐Conrat · Journal of Biological Chemistry · 1937 · 193 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin

Jacques Fastrez, Alan R. Fersht · Biochemistry · 1973 · 192 citations

Life Sciences, Biochemistry, Molecular Biology +11

Enzyme-assisted semisynthesis of human insulin

Ken Inouye, Kunio Watanabe, Kazuyuki Morihara et al. · Journal of the American Chemical Society · 1979 · 144 citations

Life Sciences, Biochemistry, Endocrinology +10

α-Chymotrypsin as the catalyst for peptide synthesis

Kazuyuki Morihara, Tatsushi Oka · Biochemical Journal · 1977 · 128 citations · Full text

Natural Sciences, Biochemistry, Chemistry +15