Journal of Medicinal Chemistry · 2002 · 101 citations · 16 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAntiparasitic ChemotherapyChagas DiseaseEnzyme InhibitionLead Compound DesignProtozoan PathogenesisStructure-activity Relationship AnalysisAntimalarial ChemotherapyTreatment Of TrypanosomiasisTrypanocidal TherapyTrypanosoma Cruzi InfectionTrypanosome InfectionsX-ray Diffraction AnalysisX-ray Spectral Analysis
An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas. Our research comprises the synthesis and trypanocidal screening of derivatives from naphthoquinones. Herein a new phenazine, obtained from the reaction of beta-lapachone with aniline, has its structure established by physical data and X-ray analysis. It was 9 times more active against T. cruzi trypomastigotes than crystal violet.
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Jussara N. Lopes, Fernando S. Cruz, Roberto Docampo et al. · Annals of Tropical Medicine and Parasitology · 1978 · 112 citations