Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells

Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets

Bianca Rocca, Paola Secchiero, Giovanni Ciabattoni et al. · Proceedings of the National Academy of Sciences · 2002 · 320 citations

Life Sciences, Cell Biology, Hematology +17

Diosgenin, a Steroid Saponin of <i>Trigonella foenum graecum</i> (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells

Jayadev Raju, Jagan M.R. Patlolla, Malisetty V. Swamy et al. · Cancer Epidemiology Biomarkers & Prevention · 2004 · 291 citations

Medicine, Oncology, Pharmacology +15

A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells

Sandra Moalic, Bertrand Liagre, Cécile Corbière et al. · FEBS Letters · 2001 · 191 citations

Life Sciences, Cell Biology, Oncology +14

Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

Cécile Corbière, Bertrand Liagre, Faraj Terro et al. · Cell Research · 2004 · 169 citations

Life Sciences, Cell Biology, Oncology +17

Regulation of megakaryocyte phenotype in human erythroleukemia cells.

Michael W. Long, C H Heffner, J. Williams et al. · Journal of Clinical Investigation · 1990 · 165 citations · Full text

Life Sciences, Cell Biology, Hematology +14