Creatinine Concentration of Human Fingernail and Toenail Clippings

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Article1 February 1966Creatinine Concentration of Human Fingernail and Toenail ClippingsApplication in Determining the Duration of Renal FailureJOHN I. LEVITT, M.D.JOHN I. LEVITT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-312 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe differentiation between acute and chronic renal failure in a patient who presents with uremia is often extremely difficult. With the advent of artificial dialysis this distinction has become of more than academic interest, since most centers are prepared to temporarily dialyze the patient with acute renal failure in the hope of eventual recovery, whereas they are not prepared to do chronic dialysis on those patients with end-stage renal disease.It was postulated that the concentration of creatinine in fingernail and toenail clippings might be of value in separating acute from chronic uremia. If nail creatinine concentration were a reflection...References1. VAN PILSUMMARTINKITOHESS JFRPEJ: Determination of creatine, creatinine, arginine, guanidinoacetic acid, guanidine, and methyl guanidine in biological fluids. J. Biol. Chem. 222: 225, 1956. CrossrefMedlineGoogle Scholar2. PETERS JH: The determination of creatinine and creatine in blood and urine with the photoelectric colorimeter. J. Biol. Chem. 146: 179, 1942. CrossrefGoogle Scholar3. CHASSONGRADYSTANLEY ALHJMA: Determination of creatinine by means of automatic chemical analysis. Amer. J. Clin. Path. 35: 83, 1961. CrossrefGoogle Scholar4. MARSHFINGERHUTKIRSCH WHBE: Determination of urea nitrogen with the diacetyl method and an automatic dialyzing apparatus. Amer. J. Clin. Path. 28: 681, 1957. CrossrefMedlineGoogle Scholar5. BOLLIGERGROSS AR: Nitrogenous compounds in the aqueous extract of vertebrate keratinous structures. Aust. J. Exp. Biol. Med. Sci. 30: 399, 1952. CrossrefMedlineGoogle Scholar6. BOLLIGERGROSS AR: Non keratins of human toenails. Aust. J. Exp. Biol. Med. Sci. 31: 127, 1953. CrossrefMedlineGoogle Scholar7. PETERSVAN SLYKE JPDD: Quantitative Clinical Chemistry, vol. II. Williams & Wilkins Co., Baltimore, 1932, chapt. XV. Google Scholar8. LE GROS CLARKBUXTON WELH: Studies in nail growth. Brit. J. Derm. 50: 221, 1938. CrossrefGoogle Scholar9. PARDO-CASTELLOPARDO VOA: Diseases of the Nails, 3rd ed. Charles C Thomas, Springfield, Ill., 1960, p. 13. Google Scholar10. BEAN WB: A note on fingernail growth. J. Invest. Derm. 20: 27, 1953. CrossrefMedlineGoogle Scholar11. PILLSBURYSHELLEYKLIGMAN DMWBAM: Dermatology. W. B. Saunders Co., Philadelphia, 1956, p. 32. Google Scholar12. BOLLIGERGROSS AR: Ammonia, urea, and uric acid content of toenails in renal insufficiency and gout. Aust. J. Exp. Biol. Med. Sci. 31: 385, 1953. CrossrefMedlineGoogle Scholar13. KOPITOMAHMOODIANTOWNLEYKHAWSCHWACHMAN LARRKTH: Studies in cystic fibrosis: analysis of nail clippings for sodium and potassium. New Eng. J. Med. 272: 504, 1965. CrossrefMedlineGoogle Scholar14. ELIAHOUPOPOVTZER HEMM: Phosphorus excretion in acute and chronic renal disease. Lancet 1: 422, 1963. CrossrefGoogle Scholar15. OLSSON O: Some radiological problems connected with Bright's disease. Brit. J. Radiol. 27: 86, 1954. CrossrefMedlineGoogle Scholar16. ALWALLERLANSONNYMANTORNBERG NPMA: On the artificial kidney, XXX—Casuistics of a further 26 severe cases of glomerulonephritis treated conservatively and, on vital indication, by dialysis (26 cases) and ultrafiltration (2 cases). Acta Med. Scand. 152: 417, 1955. CrossrefMedlineGoogle Scholar17. MOELL H: Kidney size and its deviation from normal in acute renal failure. Acta Radiol. Supplement 206: 1, 1961. Google Scholar18. ALLEN AC: The Kidney: Medical and Surgical Diseases, 2nd ed. Grune & Stratton, Inc., New York, 1962, p. 287. Google Scholar19. Ibid., pp. 183-188. Google Scholar20. BELL ET: Renal Diseases, 2nd ed. Lea & Febiger, Philadelphia, 1950, chapt. VI. Google Scholar21. BRUNGORMSENHILDENIVERSONRAASCHOU CHTPF: Kidney biopsy in acute glomerulonephritis. Acta Med. Scand. 160: 155, 1958. CrossrefMedlineGoogle Scholar22. DODGEDAESCHNERBRENNANROSENBERGTRAVISHOPPS WFCWJCHSLBHC: Percutaneous renal biopsy in children. II. Acute glomerulonephritis, chronic glomerulonephritis, and nephritis of anaphylactoid purpura. Pediatrics 30: 297, 1962. MedlineGoogle Scholar23. VERNIERWORTHENWANNAMAKERGOOD RLHGLWRA: Renal biopsy studies of the acute exacerbation in glomerulonephritis. Amer. J. Dis. Child. 98: 653, 1959. Google Scholar24. JENNINGSEARLE RBDP: Post-streptococcal glomerulonephritis; histopathologic and clinical studies of the acute, subsiding acute and early chronic latent phases. J. Clin. Invest. 40: 1525, 1961. CrossrefMedlineGoogle Scholar25. HARRISONLOUGHRIDGEMILNE CVLWMD: Acute oliguric renal failure in acute glomerulonephritis and polyarteritis nodosa. Quart. J. Med. 33: 39, 1964. MedlineGoogle Scholar26. BERLYNEBAKER GMSB: Acute anuric glomerulonephritis. Ibid., p. 1055. Google Scholar27. EDELMANNGREIFERBARNETT CMIHL: The nature of kidney disease in children who fail to recover from apparent glomerulonephritis. J. Pediat. 64: 879, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn.This study was supported by grants 63-G-172 and 64-G-11 from the American Heart Association, Inc., New York, N. Y., and by grant HE08775 from the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to John I. Levitt, M.D., Box 240, >Department of Medicine, University of Minnesota Hospitals, Minneapolis, Minn. 55455. 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