Automated Parallel Synthesis of a Protected Oligosaccharide Library Based upon the Structure of Dimeric Lewis X by One-Pot Sequential Glycosylation

Abstract

An efficient synthesis of a protected dimeric Lewis X epitope by two sequential one-pot glycosylations is described. Combinatorial synthesis of the dimeric Lewis X epitope derivatives by the one-pot glycosylation was accomplished utilizing an automated synthesizer to provide 12-protected oligosaccharides.