An efficient method for the stereoselective synthesis of cis -3-substituted prolines: conformationally constrained α-amino acids

A new approach to kainoids through tandem Michael reaction methodology: application to the enantioselective synthesis of (+)- and (-)-.alpha.-allokainic acid and to the formal synthesis of (-)-.alpha.-kainic acid

A. BARCO, Simonetta Benetti, Giampiero Spalluto et al. · The Journal of Organic Chemistry · 1992 · 84 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

2,3-Pyrrolidinedicarboxylates as Neurotransmitter Conformer Mimics: Enantioselective Synthesis via Chelation-Controlled Enolate Alkylation

John M. Humphrey, Richard J. Bridges, Jill A. Hart et al. · The Journal of Organic Chemistry · 1994 · 83 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7

Conformationally constrained amino acids. Synthesis and optical resolution of 3-substituted proline derivatives

John Y. L. Chung, James T. Wasicak, William A. Arnold et al. · The Journal of Organic Chemistry · 1990 · 81 citations

Natural Sciences, Biochemistry, Chemistry +16

New strategy for the synthesis of 3-substituted prolines

Philippe Karoyan, Gérard Chassaing · Tetrahedron Letters · 1997 · 77 citations

Natural Sciences, Chemistry, Medicinal Chemistry +4

On the Stereochemical Divergence in the Conjugate Addition of Lithium Dimethylcuprate/Trimethylsilyl Chloride to γ-Alkoxy and γ-Ureido α,β-Unsaturated Esters

Stephen Hanessian, Kenzo Sumi · Synthesis · 1991 · 75 citations

Natural Sciences, Chemistry, Organic Chemistry +8