Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Ataxia telangiectasia-mutated phosphorylates Chk2 <i>in vivo</i> and <i>in vitro</i>

Shuhei Matsuoka, Galit Rotman, Akira Ogawa et al. · Proceedings of the National Academy of Sciences · 2000 · 823 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

A Randomized Trial of Intravesical Doxorubicin and Immunotherapy with Bacille Calmette–Guérin for Transitional-Cell Carcinoma of the Bladder

Donald L. Lamm, Brent A. Blumenstein, E. David Crawford et al. · New England Journal of Medicine · 1991 · 617 citations · Full text

Medicine, Oncology, Urology +13

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Xiongbin Lu, Bonnie Nannenga, Lawrence A. Donehower · Genes & Development · 2005 · 384 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity

Patrick W. Fisher, Fadi N. Salloum, Anindita Das et al. · Circulation · 2005 · 350 citations · Full text

Medicine, Cardiology, Pharmacology +17