PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Tong Cheng, Dong Liu, John H. Griffin et al. · Nature Medicine · 2003 · 559 citations

Life Sciences, Cell Biology, Neuroscience +16

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

Girish Putcha, Krista L. Moulder, Judith P. Golden et al. · Neuron · 2001 · 449 citations · Full text

Life Sciences, Cell Biology, Neuroscience +15

Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model

Kevin R. Lee, Nobuyuki Kawai, Seoung Kim et al. · Journal of neurosurgery · 1997 · 365 citations

Medicine, Neurobiology, Neuroscience +17

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins

Lixin Zhang, Jing Chen, Haian Fu · Proceedings of the National Academy of Sciences · 1999 · 357 citations

Life Sciences, Cell Biology, Molecular Biology +17

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

Frank Striggow, Monika Riek, Jörg Breder et al. · Proceedings of the National Academy of Sciences · 2000 · 285 citations

Medicine, Neurobiology, Neuroscience +16