Concepedia

Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

Luc H. Boudreau, J. Maillet, Luc M. LeBlanc, Jacques Jean‐François, Mohamed Touaibia, Nicolas Flamand, Marc E. Surette

PLoS ONE · 2012 · 69 citations · 45 references

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Abstract

CAPE is a potent LT biosynthesis inhibitor that blocks 5-LO activity and AA release. The CAPE structure can be used as a framework for the rational design of stable and potent inhibitors of LT biosynthesis.

References

45

Isolation of mononuclear cells and granulocytes from human blood.

Arne Bøyum · Scandinavian Journal of Clinical and Laboratory Investigation · 1968 · 9.6K citations

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Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

PubMed · 1968 · 5.3K citations

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Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

Bengt Samuelsson · Science · 1983 · 2.8K citations

Effects of the interaction of tannins with Co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical.

Tsutomu Hatano, Rei Edamatsu, Midori Hiramatsu et al. · Chemical and Pharmaceutical Bulletin · 1989 · 767 citations · Full text

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Montelukast, a Leukotriene-Receptor Antagonist, for the Treatment of Mild Asthma and Exercise-Induced Bronchoconstriction

Jonathan A. Leff, David S. Pearlman, Edwin A. Bronsky et al. · New England Journal of Medicine · 1998 · 555 citations · Full text