Concepedia

Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells

Hai Xu, Laura P. Stabile, Christopher T. Gubish, William E. Gooding, Jennifer R. Grandis, Jill M. Siegfried

Clinical Cancer Research · 2011 · 117 citations · 34 references

DOIFull text

Open access

Abstract

Together, these results suggest that dual blockade of c-Met and EGFR may be a promising clinical therapeutic strategy for treating HNSCC.

References

34

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.1K citations

, , +10

<i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science · 2007 · 4.4K citations

Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

Jennifer R. Grandis, Mona F. Melhem, William E. Gooding et al. · JNCI Journal of the National Cancer Institute · 1998 · 1.1K citations · Full text

Open-Label, Uncontrolled, Multicenter Phase II Study to Evaluate the Efficacy and Toxicity of Cetuximab As a Single Agent in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Who Failed to Respond to Platinum-Based Therapy

Jan B. Vermorken, José Trigo, Ricardo Hitt et al. · Journal of Clinical Oncology · 2007 · 996 citations · Full text

Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

Jayne M. Stommel, Alec C. Kimmelman, Haoqiang Ying et al. · Science · 2007 · 915 citations

, , +21