Concepedia

Met-targeted Therapy

MET-Targeted Therapy is a therapeutic strategy within systemic oncology that selectively inhibits the MET receptor tyrosine kinase or its downstream signaling pathways to suppress tumor growth and metastasis in thoracic malignancies harboring MET pathway aberrations.

684

Publications

48.1K

Citations

5.4K

Authors

1.4K

Institutions

Publications per year

2017–2026

302

Variants

Met-directed Therapy

Parents

Publications

684

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova, Wesley Blackaby, Mark R. Albertella et al. · Nature · 2021 · 1.3K citations · Full text

, , +13

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

F. Michael Yakes, Jason Chen, Jenny Tan et al. · Molecular Cancer Therapeutics · 2011 · 1.3K citations · Full text

, , +17

Capmatinib in <i>MET</i> Exon 14–Mutated or <i>MET</i> -Amplified Non–Small-Cell Lung Cancer

Jürgen Wolf, Takashi Seto, Ji‐Youn Han et al. · New England Journal of Medicine · 2020 · 997 citations · Full text

, , +15

Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial

David Planchard, Benjamin Besse, Harry J.M. Groen et al. · The Lancet Oncology · 2016 · 878 citations · Full text

, , +12

An overview of the c-MET signaling pathway

Shawna Organ, Ming‐Sound Tsao · Therapeutic Advances in Medical Oncology · 2011 · 864 citations · Full text

, , +17

1–5 of 684

Authors

5.4K

  1. RS
    Ravi Salgia

    University of Chicago, United States

    33 publications · 5.1K citations

    23

    h-index

  2. DR
    D. Ross Camidge

    University of Colorado Denver, United States

    26 publications · 2.6K citations

    20

    h-index

  3. DS
    David S. Hong

    The University of Texas MD Anderson Cancer Center, United States

    18 publications · 1.4K citations

    16

    h-index

  4. SI
    Sai‐Hong Ignatius Ou

    University of California, Irvine, United States

    17 publications · 3.1K citations

    15

    h-index

  5. JG
    James G. Christensen

    Pfizer (United States), United States

    17 publications · 2.9K citations

    15

    h-index

1–5 of 5.4K

Institutions

1.4K

  1. Dana-Farber Cancer Institute

    Boston, United States

    29 h-index

    200 publications

    16.4K citations

  2. Massachusetts General Hospital

    Boston, United States

    28 h-index

    102 publications

    12.7K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    27 h-index

    220 publications

    17.9K citations

  4. Memorial Sloan Kettering Cancer Center

    New York, United States

    24 h-index

    191 publications

    21.4K citations

  5. University of Chicago

    Chicago, United States

    24 h-index

    124 publications

    15.2K citations

  6. Samsung Medical Center

    Seoul, South Korea

    20 h-index

    76 publications

    4.7K citations

  7. University of Colorado Denver

    Denver, United States

    20 h-index

    62 publications

    5.9K citations

  8. University of California, Los Angeles

    Los Angeles, United States

    19 h-index

    35 publications

    2.3K citations

1–8 of 1.4K

Venues

  1. Journal of Clinical Oncology

    101 publications · 7.4K citations

    40

    h-index

  2. Clinical Cancer Research

    36 publications · 3.1K citations

    33

    h-index

  3. Cancer Research

    29 publications · 3.2K citations

    23

    h-index

  4. Molecular Cancer Therapeutics

    MCT · 28 publications · 2.7K citations

    21

    h-index

  5. Journal of Thoracic Oncology

    23 publications · 2K citations

    19

    h-index

1–5