Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response

The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia

Stanley R. Kay, Abraham Fiszbein, Lewis A. Opler · Schizophrenia Bulletin · 1987 · 21.4K citations · Full text

Social Sciences, Psychiatry, Psychology +17

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

Herbert Y. Meltzer, Shin Matsubara, J C Lee · Journal of Pharmacology and Experimental Therapeutics · 1989 · 1.4K citations

Medicine, Pharmacology, Psychiatry +17

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

Colleen Burns, H. M. Chu, Susan M. Rueter et al. · Nature · 1997 · 1K citations

Life Sciences, Molecular Biology, Pharmacology +12

The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers

Tiina Pohjalainen, Juha O. Rinne, Kjell Någren et al. · Molecular Psychiatry · 1998 · 683 citations

Life Sciences, Genetics, Neuroscience +12

D2 dopamine receptor gene (DRD2) Taql A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele

J. Thompson, Natalie Thomas, Andrew Singleton et al. · Pharmacogenetics · 1997 · 560 citations

Life Sciences, Genetics, Neuroscience +12