Simulation and experimental validation of micro polymerase chain reaction chips

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A. Manz, David Harrison, Elisabeth Verpoorte et al. · Journal of Chromatography A · 1992 · 1K citations

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DNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA.

Michael A. Innis, K B Myambo, David H. Gelfand et al. · Proceedings of the National Academy of Sciences · 1988 · 779 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

Functional Integration of PCR Amplification and Capillary Electrophoresis in a Microfabricated DNA Analysis Device

Adam T. Woolley, Dean Hadley, Phoebe Landre et al. · Analytical Chemistry · 1996 · 728 citations

Engineering, Bioengineering, Biotechnology +16

A Miniature Analytical Instrument for Nucleic Acids Based on Micromachined Silicon Reaction Chambers

M. Allen Northrup, Bill Benett, Dean Hadley et al. · Analytical Chemistry · 1998 · 265 citations

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Rapid cycle DNA amplification: time and temperature optimization.

Carl T. Wittwer, D. J. H. Garling · PubMed · 1991 · 241 citations

Life Sciences, Biotechnology, Molecular Biology +13