Concepedia

The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial–stellate cell deactivation induced by statins

Giusi Marrone, Lucia Russo, Eugenio Rosado, Diana Hide, Guillermo García‐Cardeña, Juan Carlos García‐Pagán, Jaime Bosch, Jordi Gracia‐Sancho

Journal of Hepatology · 2012 · 240 citations · 27 references

DOI

Concepts

References

27

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima et al. · Nature Medicine · 2000 · 1.4K citations

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KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation

Sucharita SenBanerjee, Zhiyong Lin, G. Brandon Atkins et al. · The Journal of Experimental Medicine · 2004 · 729 citations · Full text

, , +17

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

Kush M. Parmar · Journal of Clinical Investigation · 2005 · 695 citations · Full text

, , +17

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2)

Rob J. Dekker, S. van Soest, Ruud D. Fontijn et al. · Blood · 2002 · 687 citations · Full text

, , +14

Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial

Juan G. Abraldeṣ, Agustı́n Albillos, Rafael Bañares et al. · Gastroenterology · 2009 · 460 citations · Full text

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