Perfusion-limited effects of plasma drug binding on hepatic drug extraction

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

The Disposition of Propranolol

David G. Shand, Robert E. Rangno · Pharmacology · 1972 · 233 citations

Molecular Pharmacology, Propranolol Concentrations, Dose Dependent Kinetics +10

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

Gwyn H. Evans, Alan S. Nies, David G. Shand · PubMed · 1973 · 206 citations

Mammalian Physiology, Quantitative Pharmacology, Pharmacotherapy +23

The Disposition of Propranolol

David G. Shand, Robert E. Rangno, Gwyn H. Evans · Pharmacology · 1972 · 186 citations

Pharmacotherapy, Experimental Pharmacology, Propranolol Extraction +16

Effect of Plasma Protein Binding on Elimination of Warfarin

Gerhard Levy, Avraham Yacobi · Journal of Pharmaceutical Sciences · 1974 · 125 citations

Inflammation, Thrombosis, Medicine +8