Concepedia

Involvement of Rho-Kinase Pathway in Contractile Activity of Rabbit RPE Cells In Vivo and In Vitro

Yuping Zheng, Hajime Bando, Yasushi Ikuno, Yusuke Oshima, Miki Sawa, Masahito Ohji, Yasuo Tano

Investigative Ophthalmology & Visual Science · 2004 · 35 citations · 41 references

Abstract

Y27632 decreased alpha-SMA expression and the contractile force generated by RPE cells and attenuated PVR, indicating the involvement of the Rho-kinase pathway in cell-dependent collagen contraction in vitro and in vivo. The drug may affect the biological event by inhibiting alpha-SMA expression, and Y27632 could be useful for preventing PVR.

References

41

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

Hypertension, Muscle Function, Signal Transduction +11

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

Mutsuki Amano, Masaaki Ito, Kazushi Kimura et al. · Journal of Biological Chemistry · 1996 · 2K citations · Full text

Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

Boris Hinz, Giuseppe Celetta, James J. Tomasek et al. · Molecular Biology of the Cell · 2001 · 1.3K citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

Mutsuki Amano, Kazuyasu Chihara, Kazushi Kimura et al. · Science · 1997 · 1.1K citations

Engineering, Cell Adhesion, Cytoskeleton +20

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

Takeshi Matsui, Mutsuki Amano, Takahisa Yamamoto et al. · The EMBO Journal · 1996 · 1.1K citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +10