First synthesis of (1R,2R,3S,9S,9aR)-1,2,3,9-tetrahydroxy-quinolizidine, a novel isosteric homologue of the glucosidase inhibitor castanospermine

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

Rob A. Gruters, Jacques Neefjes, Matthijs Tersmette et al. · Nature · 1987 · 579 citations

Life Sciences, Infectious Diseases, Molecular Biology +14

Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe

Liza D. Hohenschutz, E.Arthur Bell, Phillip J. Jewess et al. · Phytochemistry · 1981 · 374 citations

Life Sciences, Botany, Plant Sciences +11

Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.

Bruce D. Walker, Mark Kowalski, W C Goh et al. · Proceedings of the National Academy of Sciences · 1987 · 338 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors.

Martin J. Humphries, Kazue Matsumoto, Sandra L. White et al. · PubMed · 1986 · 315 citations

Medicine, Oncology, Pharmacology +16

Castanospermine, a tetrahydroxylated alkaloid that inhibits β-glucosidase and β-glucocerebrosidase

Rick Saul, James P. Chambers, Russell J. Molyneux et al. · Archives of Biochemistry and Biophysics · 1983 · 296 citations

Life Sciences, Biochemistry, Medicinal Chemistry +12