Günther Gradnig

Two isosteric fluorinated derivatives of the powerful glucosidase inhibitors, 1-deoxynojirimycin and 2,5-dideoxy-2,5-imino-d-mannitol: Syntheses and glucosidase-inhibitory activities of 1,2,5-trideoxy-2-fluoro-1,5-imino-d-glucitol and of 1,2,5-trideoxy-1-fluoro-2,5-imino-d-mannitol

Søren Andersen, Michael Ebner, Christian W. Ekhart et al. · Carbohydrate Research · 1997 · 61 citations

Pharmacy, Medicinal Chemistry, Carbohydrate Chemistry +8

2,5-dideoxy-2,5-imino-d-mannitol and -d-glucitol. Two-step bio-organic syntheses from 5-azido-5-deoxy-d-glucofuranose and -l-idofuranose; evaluation as glucosidase inhibitors and application in affinity purification and characterisation of invertase from yeast

Günter Legler, Annette Korth, Christian W. Ekhart et al. · Carbohydrate Research · 1993 · 40 citations

Life Sciences, Biochemistry, Biotechnology +16

First synthesis of (1R,2R,3S,9S,9aR)-1,2,3,9-tetrahydroxy-quinolizidine, a novel isosteric homologue of the glucosidase inhibitor castanospermine

Günther Gradnig, Andreas Berger, V. Grassberger et al. · Tetrahedron Letters · 1991 · 38 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

A novel synthetic application of glucose isomerase: Quantitative conversion of D-glucose and L-idofuranose, derivatives modified at position five into the corresponding D-fructo- and L-sorbopyranoses.

Andreas Berger, Anna De Raadt, Günther Gradnig et al. · Tetrahedron Letters · 1992 · 29 citations

Life Sciences, Biochemistry, Biotechnology +15

A novel approach to the 1-deoxynojirimycin system: Synthesis from sucrose of 2-acetamido-1,2-dideoxynojirimycin, as well as some 2-N-modified derivatives

Günther Gradnig, Günter Legler, Arnold Stütz · Carbohydrate Research · 1996 · 25 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +3