Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade

Mutation and Cancer: Statistical Study of Retinoblastoma

Alfred G. Knudson · Proceedings of the National Academy of Sciences · 1971 · 7.5K citations · Full text

Tumor Biology, Somatic Variant, Tumor Heterogeneity +13

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

Cathy A. Finlay, Philip W. Hinds, Tse‐Hua Tan et al. · Molecular and Cellular Biology · 1988 · 1.1K citations · Full text

Gene Product, Hsc70-p53 Complex, Amino Acids +16

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xiaoling Xu, Kay‐Uwe Wagner, Denise M. Larson et al. · Nature Genetics · 1999 · 765 citations

Conditional Mutation, Tumor Biology, Tumour Formation +12

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

Keisuke Kurose, Kristie Gilley, Satoshi Matsumoto et al. · Nature Genetics · 2002 · 422 citations

Breast Oncology, Somatic Variant, Medicine +9

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

Cindy Wilson, Lillian Ramos, Maria R. Villaseñor et al. · Nature Genetics · 1999 · 416 citations

Tumor Biology, Breast Oncology, Medicine +9