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Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

DOIFull Paper Access

66

Citations

24

References

2011

Year

Rohan Samarakoon, Subhanir S. Chitnis, Stephen P. Higgins, Craig E. Higgins, Joan C. Krepinsky, Paul J. Higgins
PLoS ONE

Abstract

TGF-β1-initiated Src-dependent caveolin-1(Y14) phosphorylation is a critical event in Rho-ROCK-mediated suppression of nuclear PPM1A levels maintaining, thereby, SMAD2/3-dependent transcription of the PAI-1 gene.

References

YearCitations

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