Concepedia

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Manuela Tosin, Yuliya Demydchuk, James S. Parascandolo, Covadonga Blasco Per, Finian J. Leeper, Peter F. Leadlay

Chemical Communications · 2011 · 30 citations · 21 references

DOI

Concepts

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

References

21

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, , +10

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