Publication | Closed Access
Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate
90
Citations
9
References
2007
Year
Hcv RepliconDevelopment CandidateMolecular BiologyPyrrolidine-based TemplateAntiviral DrugChemical BiologyPharmaceutical ChemistryMedicinal ChemistryViral HepatitisAntiviral Drug DevelopmentStructure-based DesignBiochemistryVirologyPharmacologyAntiviral CompoundNatural SciencesRational Drug DesignAntiviral TherapyHepatitisMedicineDrug Discovery
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
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