Concepedia

Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate

Martin J. Slater, Elizabeth M. Amphlett, David Andrews, Gianpaolo Bravi, George Burton, Anne Cheasty, John Corfield, Malcolm Ellis, Rebecca H. Fenwick, Stephanie Fernandes,

Journal of Medicinal Chemistry · 2007 · 90 citations · 9 references

DOI

Concepts

Abstract

Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.

References

9

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

Volker Lohmann, Frank Körner, Jan Oliver Koch et al. · Science · 1999 · 2.8K citations

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Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.

Sven‐Erik Behrens, Licia Tomei, Raffaele De Francesco · The EMBO Journal · 1996 · 685 citations · Full text

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Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo

Alexander A. Kolykhalov, Kathy Mihalik, Stephen M. Feinstone et al. · Journal of Virology · 2000 · 592 citations · Full text

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Positive Selection of Natural Autoreactive B Cells

Kyoko Hayakawa, Masanao Asano, Susan A. Shinton et al. · Science · 1999 · 570 citations

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

Stéphane Bressanelli, Licia Tomei, Alain Roussel et al. · Proceedings of the National Academy of Sciences · 1999 · 568 citations

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