Anne Cheasty

MNK Inhibition Sensitizes <i>KRAS</i> -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

John R. P. Knight, George Skalka, Nikola Vlahov et al. · Cancer Discovery · 2020 · 95 citations · Full text

Medicine, Molecular Biology, Oncology +17

Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate

Martin J. Slater, Elizabeth M. Amphlett, David Andrews et al. · Journal of Medicinal Chemistry · 2007 · 90 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Niall Igoe, Elliott D. Bayle, Oleg Fedorov et al. · Journal of Medicinal Chemistry · 2017 · 53 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

Niall Igoe, Elliott D. Bayle, C. Tallant et al. · Journal of Medicinal Chemistry · 2017 · 37 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

M. Raymond V. Finlay, Mark J. Anderton, Andrew Bailey et al. · Journal of Medicinal Chemistry · 2019 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15