Angewandte Chemie International Edition · 1998 · 62 citations · 0 references
MedicineBiochemistryPharmacologyCarbohydrate BiochemistryCarbohydrate ChemistryHemostasisAnticoagulant TherapyAnticoagulation TherapyAntithrombotic TherapyCarbohydrate StructureCarbohydrate SynthesisThrombosis PreventionAnticoagulant MechanismsAntithrombin RegulationCarbohydrate Building Block SynthesisHeparin AnticoagulationHeparin-mediated AnticoagulationNatural Anticoagulant ProteinsPlasma Anticoagulant ActivityThrombin Inhibition
A single disaccharide building block is required to obtain synthetic carbohydrates that reproduce the anticoagulant activity of heparin and inhibit thrombin (n>6) and/or factor Xa (n≥2; see reaction scheme). Thus, there is evidence that heparin fragments with at least 15 saccharide units are required for thrombin inhibition. Lev=levulinoyl.