The presenilin C‐terminus is required for ER‐retention, nicastrin‐binding and γ‐secretase activity

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature · 1992 · 1.7K citations

Life Sciences, Molecular Biology, Neurology +16

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +13

A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels

Noa Zerangue, Blanche Schwappach, Yuh Nung Jan et al. · Neuron · 1999 · 1K citations · Full text

Natural Sciences, Biochemistry, Molecular Biology +14

Reconstitution of γ-secretase activity

Dieter Edbauer, Edith Winkler, Jörg T. Regula et al. · Nature Cell Biology · 2003 · 875 citations

Life Sciences, Biochemistry, Molecular Biology +11

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

Tommy Nilsson, Michael R. Jackson, Per A. Peterson · Cell · 1989 · 496 citations

Life Sciences, Cell Biology, Molecular Biology +10