Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

Microencapsulated Islets as Bioartificial Endocrine Pancreas

Franklin Lim, Anthony M. Sun · Science · 1980 · 2.4K citations

Engineering, Bioengineering, Biomedical Engineering +17

Growth of Cell-strains and Primary Cells on Micro-carriers in Homogeneous Culture

A. L. van Wezel · Nature · 1967 · 704 citations

Life Sciences, Biology, Microbiology +12

Cell Culture on Artificial Capillaries: An Approach to Tissue Growth in vitro

Richard A. Knazek, Pietro M. Gullino, Peter Köhler et al. · Science · 1972 · 428 citations

Engineering, Bioengineering, Biomedical Engineering +16

Factors affecting cell growth and monoclonal antibody production in stirred reactors

Shaul Reuveny, Daniel Uribe-Vélez, James D. Macmillan et al. · Journal of Immunological Methods · 1986 · 267 citations

Engineering, Biotechnology, Chemical Engineering +16