A TNF receptor antagonistic scFv, which is not secreted in mammalian cells, is expressed as a soluble mono- and bivalent scFv derivative in insect cells

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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

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Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay

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Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line.

John V. Kilmartin, B Wright, C. Milstein · The Journal of Cell Biology · 1982 · 941 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

Takashi Yokota, Diane E. Milenic, Marc Whitlow et al. · PubMed · 1992 · 826 citations

Pharmacy, Oncology, Pharmacokinetics +17