Organic Letters · 2001 · 31 citations · 23 references
PharmacyChemistryMedicinal ChemistryDrug DesignDrug DiscoverySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisPeptide ChemistryPhotochemical SynthesisPhotochemistryBicyclic Peptide DesignBioactive HeterocyclesMacrocyclic PeptidesPhotochemical ProcessesPhotochemical RearrangementPhotocyclization ReactionsRgd Peptides
[reaction: see text] Photolysis of oxaziridines a or nitrones b provides a convenient synthetic route to fused bicyclic lactams c adequately substituted on both cycles A and B as scaffolds for mimicking conformationally constrained beta-turn peptides as in the tripeptide RGD signaling motif of fibronectin.
23