Exogenous Basic Fibroblast Growth Factor Inhibits <scp>ER</scp> Stress–Induced Apoptosis and Improves Recovery from Spinal Cord Injury

Abstract

This is the first study to illustrate that the role of bFGF in SCI recovery is related to the inhibition of ER stress-induced cell death via the activation of downstream signals. Our work also suggested a new trend for bFGF drug development in central neural system injuries, which are involved in chronic ER stress-induced apoptosis.