Concepedia

Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats

Blandine Lefebvre, Françoise Caron, Germain Bessard, Françoise Stanke‐Labesque

Journal of Hypertension · 2005 · 12 citations · 35 references

DOI

Abstract

These data suggested that 5-LO-derived products, through the activation of cysLT1 receptors, could be involved in the endothelium-dependent contraction to acetylcholine in aorta from SHR but not in the regulation of MABP in SHR.

References

35

Characterization of the human cysteinyl leukotriene CysLT1 receptor

Kevin R. Lynch, Gary P. O’Neill, Qingyun Liu et al. · Nature · 1999 · 967 citations

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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

Anna Helgadóttir, Andrei Manolescu, Sólveig Grétarsdóttir et al. · Nature Genetics · 2004 · 924 citations · Full text

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Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

Thomas F. Lüscher, Paul M. Vanhoutte · Hypertension · 1986 · 878 citations · Full text

, , +15

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Richard A. F. Dixon, Ronald E. Diehl, Evan E. Opas et al. · Nature · 1990 · 775 citations

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Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis

James H. Dwyer, Hooman Allayee, Kathleen M. Dwyer et al. · New England Journal of Medicine · 2003 · 613 citations · Full text