Concepedia

Synthesis and Biological Evaluation of Carbocyclic Analogues of Ribavirin

Stewart A. Noble, Nicola E. Beddall, Alison J. Beveridge, Clara L.P. Marr, Chi L. Mo, Peter L. Myers, Charles R. Penn, Richard Storer, Jacqueline M. Woods

Nucleosides and Nucleotides · 1991 · 12 citations · 6 references

DOI

Concepts

Abstract

Abstract A series of racemic carbocyclic analogues of Ribavirin have been prepared. Their degree of phosphorylation by adenosine kinase and the inhibition of IMPDH and RNA polymerase by their mono and mphosphates respectively is compared with Ribavirin and discussed in the context of anti-influenza activity.

References

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