Concepedia

Modulation of Vasoactivity and Platelet Aggregation by Selective 5-HT Receptor Antagonism in Humans

Matthijs Moerland, Michiel J. B. Kemme, Anneke C. Dijkmans, L. Bergougnan, Jacobus Burggraaf

Journal of Cardiovascular Pharmacology · 2011 · 20 citations · 22 references

DOI

Abstract

SL65.0472-00 has potent antagonistic effect on 5-HT-induced vasoconstriction and platelet aggregation but not on sumatriptan-induced vasoconstriction. This suggests that in humans, SL65.0472-00 is a 5-HT2A blocker without clear 5-HT1B antagonistic activity.

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