5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries

Abstract

These results show that both 5-HT1-like and 5-HT2 receptors mediate contraction of human epicardial coronary arteries and indicate that effects mediated by 5-HT1-like receptors but not 5-HT2 receptors are preserved in patients with ischaemic heart disease.