Concepedia

Quinuclidine-based NK1 antagonists, the role of the benzhydryl

Christopher J. Swain, Tung M. Fong, K. Haworth, Simon N. Owen, Eileen M. Seward, Catherine D. Strader

Bioorganic & Medicinal Chemistry Letters · 1995 · 11 citations · 6 references

DOI

Concepts

References

6

A Potent Nonpeptide Antagonist of the Substance P (NK <sub>1</sub> ) Receptor

R. Michael Snider, Jay W. Constantine, John Lowe et al. · Science · 1991 · 864 citations

, , +14

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

Tung M. Fong, Margaret A. Cascieri, H.Y. Yu et al. · Nature · 1993 · 184 citations

, , +14

Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.

Margaret A. Cascieri, E Ber, Tung M. Fong et al. · Molecular Pharmacology · 1992 · 137 citations

, , +12

Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes

Eileen M. Seward, Christopher J. Swain, Kevin J. Merchant et al. · Bioorganic & Medicinal Chemistry Letters · 1993 · 28 citations

, , +7

Quinuclidine chemistry. 2. Synthesis and antiinflammatory properties of 2-substituted benzhydryl-3-quinuclidinols

E. J. WARAWA, Nikolaus Mueller, R. Jules · Journal of Medicinal Chemistry · 1974 · 21 citations

, , +5