Microwave-Assisted Synthesis of 2,4,5-Triaryl-imidazole; A Novel Thermally Induced <i>N</i>-Hydroxyimidazole N−O Bond Cleavage

Richard Sparks, Andrew P. Combs

Organic Letters · 2004 · 89 citations · 7 references

Concepts

Abstract

[reaction: see text] 2,4,5-Triaryl-imidazoles were synthesized directly from the keto-oxime in moderate to good yields via cyclization to the N-hydroxyimidazole and an unprecedented in situ thermal reduction of the N-O bond upon microwave irradiation at 200 degrees C for 20 min.

References

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