Concepedia

Investigation of the Molecular Mechanism of the α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator PNU-120596 Provides Evidence for Two Distinct Desensitized States

Dustin K. Williams, Jingyi Wang, Roger L. Papke

Molecular Pharmacology · 2011 · 109 citations · 34 references

DOI

Concepts

References

34

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

David Colquhoun, B. Sakmann · The Journal of Physiology · 1985 · 768 citations

, , +17

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:<i>In Vitro</i>and<i>In Vivo</i>Characterization

Raymond S Hurst, Mihály Hajós, M. Raggenbass et al. · Journal of Neuroscience · 2005 · 444 citations · Full text

, , +17

On the nature of partial agonism in the nicotinic receptor superfamily

Remigijus Lapė, David Colquhoun, Lucia G. Sivilotti · Nature · 2008 · 344 citations · Full text

, , +14

Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes

Jens Halvard Grønlien, Monika Håkerud, Hilde Ween et al. · Molecular Pharmacology · 2007 · 272 citations

, , +17

Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

Gareth T. Young, Ruud Zwart, Alison Walker et al. · Proceedings of the National Academy of Sciences · 2008 · 263 citations · Full text

, , +17