Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

Richard W. Schevitz, Nicholas J. Bach, D. G. CARLSON et al. · Nature Structural & Molecular Biology · 1995 · 215 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

A new grammar for drug discovery

Mark C. Fishman, Jeffery A. Porter · Nature · 2005 · 192 citations

Medicine, Pharmacology, Drug Design +11

Finding multiple target optimal intervention in disease‐related molecular network

Kun Yang, Hongjun Bai, Qi Ouyang et al. · Molecular Systems Biology · 2008 · 190 citations · Full text

Life Sciences, Bioinformatics, Pharmacology +17

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity

Paul C. Unangst, David T. Connor, Wiaczeslaw A. Cetenko et al. · Journal of Medicinal Chemistry · 1994 · 163 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

How to design multi-target drugs

Tamás Korcsmáros, Máté Szalay, Csaba Böde et al. · Expert Opinion on Drug Discovery · 2007 · 159 citations

Pharmacy, Bioinformatics, Pharmacology +17