Pharmacokinetic Correlation Between in Vitro Hepatic Microsomal Enzyme Kinetics and in Vivo Metabolism of Imipramine and Desipramine in Rats

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

A pharmacokinetic analysis program (multi) for microcomputer.

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics · 1981 · 2.5K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Specific tricyclic antidepressant binding sites in rat brain

Rita Raisman, Michael S. Briley, Salomón Z. Langer · Nature · 1979 · 265 citations

Medicine, Neuroscience, Pharmacology +14

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model

Yasutaka Igari, Yuichi Sugiyama, Yasufumi Sawada et al. · Journal of Pharmacokinetics and Biopharmaceutics · 1983 · 104 citations

Pharmacy, Pharmacokinetics, Pharmacology +11