Age-associated alterations in hepatic glutathione-S-transferase activities

Shoichi Fujita, Hiromi Kitagawa, Harumi Ishizawa, +2

Biochemical Pharmacology

HepatologyAgingLiver PhysiologyPhysiologyAge-associated Alterations +6

Disappearance of sex difference in rat liver drug metabolism in old age

Hiromi Kitagawa, Shoichi Fujita, Tokuji Suzuki, +1

Biochemical Pharmacology

Old AgeHepatologyLongevityLiver PhysiologyPhysiology +7

Age and sex associated differences in the relative abundance of multiple species of cytochrome P-450 in rat liver microsomes

Shoichi Fujita, Hiromi Kitagawa, Masato Chiba, +3

Biochemical Pharmacology

BiologyMedicineGeneticsLiver PhysiologyRelative Abundance +9

Simultaneous Quantitation of Lidocaine and Its Four Metabolites by High-performance Liquid Chromatography: Application to studies on In Vitro and In Vivo Metabolism of Lidocaine in Rats

Ryosei Kawai, Shoichi Fujita, Tokuji Suzuki

Journal of Pharmaceutical Sciences

Medicinal ChemistryPharmacological StudyBiochemistryMedicineHigh-performance Liquid Chromatography +10

Cytochrome P450 isozymes catalyzing 4‐hydroxylation of parkinsonism‐related compound 1,2,3,4‐tetrahydroisoquinoline in rat liver microsomes

Tokuji Suzuki, Shoichi Fujita, Shizuo Narimatsu, +4

The FASEB Journal

Pharmacokinetic Correlation Between in Vitro Hepatic Microsomal Enzyme Kinetics and in Vivo Metabolism of Imipramine and Desipramine in Rats

Masato Chiba, Shoichi Fujita, Tokuji Suzuki

Journal of Pharmaceutical Sciences

Pharmacological StudyBiochemistryMedicineLiver PhysiologyVivo Metabolism +8

Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats

Shoichi Fujita, Reiko Morimoto, Masato Chiba, +2

Biochemical Pharmacology

Senescence-associated DeclineBiochemistryMedicineLiver PhysiologyPhysiology +11

Characterization of two P-450 isozymes placed in the rat CYP2D subfamily

Norihisa Ohishi, Susumu Imaoka, Tokuji Suzuki, +1

Biochimica et Biophysica Acta (BBA) - General Subjects

Molecular PharmacologyBiochemistryP-450 IsozymesMedicineNatural Sciences +4

Precursor–Metabolite Interaction in the Metabolism of Lidocaine

Tokuji Suzuki, Shoichi Fujita, Ryosei Kawai

Journal of Pharmaceutical Sciences

BiochemistryMedicineSecondary MetabolitePrecursor–metabolite InteractionIntermediary Metabolism +4

Covalent Binding of a Reactive Metabolite Derived from Propranolol and Its Active Metabolite 4-Hydroxypropranolol to Hepatic Microsomal Proteins of the Rat

Shizuo Narimatsu, Takayuki Arai, Toshiyuki Watanabe, +7

Chemical Research in Toxicology

Molecular PharmacologyCovalent BindingOxysterolBiochemistryMedicine +13